A chronic, granulomatous infection caused by Mycobacterium leprae, an acid-fast bacillus, preferentially affecting cooler regions of the body (e.g., skin, mucous membranes, peripheral nerves)
Tagged: Cell-mediated immunity
HIV is a retrovirus that integrates into CD4 T lymphocytes (a critical component of cell-mediated immunity), causing cell death and resulting in severe immunodeficiency, opportunistic infections (OI), and malignancies
Everyone with cancer runs a risk of developing some sort of infection. This is because many cancers, and the methods used to treat them, affect the immune system defenses that normally keep infections at bay.
Our first line of defense against infection is the outer and inner linings of the body—the skin and the mucous membranes. Both these barriers are punctured by the invasive procedures necessary to diagnose or treat cancer problems. Chemotherapy and radiation are particularly damaging to mucous membranes. Needles used to draw blood for testing, urinary catheters, intravenous (IV) lines, and infusion pumps used for delivering IV medications all create potential ports of entry for infectious organisms.