Choline – The Key to a Better Memory

Choline, an amino acid, may protect the brain throughout life—from the womb to very old age. Indeed, if your mother eats enough choline to satiate your fetal brain, you may enjoy a lifetime of superior intellect and not even have to worry about a declining memory as you get old. That’s a remarkable new finding from laboratory animals, that researchers say may translate to humans, although such human studies have not been done.

What researchers have found is phenomenal: That giv­ing rats choline halfway through pregnancy makes a per­manent mark on the fetal brain—dictating how its cells organize to mold and wire the brain, essentially building in an “excess memory capacity” that endures throughout life. In a series of experiments, scientists at Duke Univer­sity Medical Center fed pregnant rats normal choline, extra choline, or no choline and then studied the mental func­tioning and brains of their offspring.

Clearly, the rats that got the extra choline in the womb had vastly superior brains; as infants and adults they dis­played better memory and learning capabilities. Indeed, postmortem examinations revealed superbly efficient brain circuits for transmitting messages. The neurons in their hip­pocampus, the brain’s memory processing center, responded instantly to the tiniest electrical probe, indicating their brains were primed to learn rapidly. Awesome as it seems, the extra infusion of a single nutrient, choline, enabled nature to assemble a brain of extraordinary quality.

On the other hand, rats deprived of choline in utero had sluggish brains and impaired memory when they grew up.

AN ANTIDOTE TO MEMORY Loss

Even more startling, as the high-choline offspring entered old age, their brain function remained undiminished. Their memory did not fade, as it did in rats not given choline pre­natally. In very old age, choline-primed rats made only half as many memory errors when searching through mazes for food as did geriatric rats whose pregnant mothers had not been given extra choline.

“The ramifications of this could be profound. We’ve found that manipulating one single nutrient for a few days during gestation has a lifelong effect on how brains function. In theory, we could develop ways to signifi­cantly reduce age-related memory deficits.”—Dr. Scott Swartzwelder, neuropsychologist, Duke University

How could choline received before birth possibly be so powerful and long-lasting as to prevent memory deterio­ration in old age? Researchers speculate that choline might slow down the entire aging process, the brain included. Or, more probable, choline helps construct a brain with such a superior anatomical network of neurons and connec­tions—a large reserve of brain power and efficient mem­ory processing—that age-related erosion is insignificant to memory functioning later in life.

Choline does dramatically change the very structure of memory centers in the hippocampus and septum of the developing fetal brain, declares Dr. Steven Zeisel, M.D., a world expert on choline, and chairman of nutrition at the University of North Carolina School of Medicine at Chapel Hill. Dr. Zeisel and colleagues found that when choline is lacking, cell division in the fetal brain is reduced, cells migrate abnormally, and increasing numbers of brain cells die prematurely. “For the first time, we have shown that the very structure of the brain is influenced by what moth­ers eat during pregnancy. Mainly, the specific nutrient choline appears to be critical.”

A SECOND CHANCE

But what if your mother failed to give your fetal brain lots of choline? Will eating choline later as a child, adult, or in old age improve your mental functioning? It’s a good bet, say experts, although you cannot count on choline to com­pletely reorganize the way your brain circuits work. Still, birth does not put an end to the brain’s need for choline.

Choline is particularly essential for infants, whose brains are still developing. So if a mother missed providing lots of choline in the womb, there is a second chance. Not sur­prisingly, breast milk, also depending on a mother’s diet, is very rich in choline, which is one more brain-boosting rea­son to breast-feed. Infant formulas made from both cow’s milk and soy are required to add choline, but they do not contain as much as human breast milk.

Breast-feeding is definitely preferred, and may make a difference in your baby’s brain. “Because infant formulas vary so much from human breast milk,” says Dr. Zeisel, “it’s not unreasonable to worry that some differences in intel­lectual performance that we see could be due to changes in the availability of choline in utero and shortly after birth in some kids.”

Besides building strong brains, choline is also vital in keeping brain cells functioning throughout life. For one thing, choline is a precursor (building block) for acetyl­choline, the neurotransmitter vital to encoding memory.

When choline is in good supply, your neurons are more apt to make and release acetylcholine. Blocking production of acetylcholine in brain cells impairs memory; flooding brain cells with acetylcholine may overcome some memory deficits. That’s the theory of some drugs used to treat Alzheimer’s and dementia. Choline is a critical constituent of fat in brain cell membranes, influencing their structure and facilitating transmission of signals from the cell exte­rior to the nucleus, a momentous task. Additionally, choline helps suppress homocysteine in the blood that is associ­ated with brain disturbances, memory damage, and even Alzheimer’s, and strokes.

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According to extensive research, choline improves mem­ory and learning in many species, including rats, mice, mol­lusks, and humans. Of course, tests in laboratory animals do not prove that humans build brains the same way. But decades of research have been eerily accurate in making the leap from what happens in the brains of small mam­mals to how the human brain works. It’s probable that if scientists discover a brain secret in other mammals, it will eventually be confirmed in humans. Growing new brain cells is a prime case in point: Thirty years before it was detected in humans, scientists had demonstrated it in lab­oratory animals.

It’s unclear to what extent taking supplemental choline later in life may boost human memory or intellectual per­formance. Some studies find benefits; others do not. One recent experiment with eighty college students found improvement on tests of explicit memory in those who took 25 grams of lecithin that supplied 3750 milligrams of choline. There was no memory benefit from taking just ten grams of lecithin. Specifically, the students were better able to memorize a series of nonsense syllables about an hour and a half after taking the choline. Interestingly, the memory boost was greatest in “slow learners,” leading re­searchers to suspect that the slow learners had subnormal levels of choline to begin with. Thus, a supplement cor­rected a slight deficiency.

This may mean, they said, that choline works best to improve memory in slow learners and the elderly who may have abnormally low choline. The double-blind controlled study was conducted by psychologists at several California universities, including Stanford.

Choline has boosted memory in older adults. Florence Safford, D.S.W., of Florida International University, had forty-one healthy people, ages fifty through eighty, take 500 milligrams of choline (found in two tablespoons of lecithin granules) every day for five weeks. She says they reported diminished memory lapses, such as forgetting names, mis­placing items, remembering names on the tip of their tongue. Indeed, their memory lapses were about half those of comparable subjects not getting choline-lecithin—down from an average 35 lapses per week to 19 per week.

However, other more rigorous double-blind studies have not found mental benefits in adults taking choline. One explanation: The choline in food or supplements that gets into your bloodstream may not make it into your brain. Around middle age, the ability to transport choline from the blood to the brain tends to decline, say brain experts.

Regardless of whether high doses of choline hypes mem­ory in adults, everybody still needs choline in the diet or through supplements for optimal brain functioning. Experts now consider choline an essential or required nutrient for all ages. Your body cannot make enough choline for opti­mum health.

BRAIN ALERT: Choline has become a slowly vanish­ing nutrient as Americans switched to very low fat diets and denounced eggs, one of the richest sources of choline.

EGGS AS BRAIN FOOD

You may be surprised to learn that egg yolks are one of the highest and most reliable sources of choline. Thus, avoid­ing or severely restricting eggs may be harmful to brain functioning. The consumption of eggs has plummeted in the last thirty years due to warnings that the yolk is high in artery-clogging cholesterol. Consequently, intake of choline dropped sharply, since egg yolk is a major source of choline. Now, much new evidence shows that the amount of cholesterol in food is not a primary cause of raising cho­lesterol in the blood. High cholesterol is caused mainly by eating saturated fats, as in milk, butter, cheese, and meat.

Indeed, the egg is being exonerated. In April 1999, Har­vard researchers proclaimed that an egg a day is unlikely to increase the risk of heart disease or strokes, according to a new analysis of the Harvard Nurses’ Health Study and the Health Professionals Follow Up Study. Research tracked the egg consumption of 100,000 people for more than a decade. Harvard’s Frank B. Hu, M.D., and colleagues, concluded that a daily egg is not harmful—and may even help prevent heart disease, because eggs contain nutrients, including antioxidants, folic acid, other B vitamins, and unsaturated fat that may counteract any ill effect from the yolk’s high cholesterol. Another one of those beneficial nutrients is choline.

How Much Choline Do You Need Daily?

Adult men

Adult women Pregnant women Lactating women

How Much Is Too Much?

550 mg
425 mg

450 mg
550 mg

Upper tolerable upper daily intake for:

Children                                1000 mg

Adults                                    3500 mg

SOURCE: National Academy of Sciences.

WHERE TO FIND CHOLINE

Best food sources: Egg yolks, peanuts, wheat germ, liver, meat, fish, milk, cheese, vegetables—mainly broccoli, cab­bage, and cauliflower.

What about supplements? If you want to take choline supplements, the best bet is lecithin rather than straight choline. High doses of pure choline leave you smelling “fishy,” say experts. Lecithin, which is 20 percent choline, is a far better source. Lecithin comes in various forms (the scientific name is phosphatidylcholine), including granules that you can dissolve in a liquid, such as juice or milk, or sprinkle on cereal. A tablespoon of lecithin granules sup­plies about 250 milligrams of choline.

Lecithin supplements appear very safe, even at high doses, according to government tests.

FIVE WAYS CHOLINE BUILDS BETTER BRAINS

  • Choline is the raw material for synthesis of acetyl­choline, the memory neurotransmitter with wide­spread and diverse activity in brain cells.
  • Choline combined with fatty acids to make choline-phospholipids gives structure to cell membranes, and helps regulate transmission of signals between the cell exterior and the nucleus, a mighty influence in brain cell business.
  • Choline added to drinking water spurred growth of new dendritic spines in the cerebral cortexes of old mice. Their memory and learning improved, too.
  • Choline helps break down homocysteine, a brain toxin.

Choline in fetal brains helps dictate the very architecture and wiring, and thus the intellec­tual capacity of the brain after birth and into old age.

Jean-Paul Marat

Many tips are based on recent research, while others were known in ancient times. But they have all been proven to be effective. So keep this website close at hand and make the advice it offers a part of your daily life.

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